KMID : 1039420230570010060
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Journal of Pathology and Translational Medicine 2023 Volume.57 No. 1 p.60 ~ p.66
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Inflammatory bowel disease?associated intestinal fibrosis
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Park Ji-Min
Kim Jeong-Seok Lee Yoo-Jin Bae Sung-Uk Lee Hye-Won
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Abstract
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Fibrosis is characterized by a proliferation of fibroblasts and excessive extracellular matrix following chronic inflammation, and this replacement of organ tissue with fibrotic tissue causes a loss of function. Inflammatory bowel disease (IBD) is a chronic inflammation of the gastrointestinal tract, and intestinal fibrosis is common in IBD patients, resulting in several complications that require surgery, such as a stricture or penetration. This review describes the pathogenesis and various factors involved in intestinal fibrosis in IBD, including cytokines, growth factors, epithelial-mesenchymal and endothelial-mesenchymal transitions, and gut microbiota. Furthermore, histopathologic findings and scoring systems used for stenosis in IBD are discussed, and differences in the fibrosis patterns of ulcerative colitis and Crohn¡¯s disease are compared. Biomarkers and therapeutic agents targeting intestinal fibrosis are briefly mentioned at the end.
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KEYWORD
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Fibrosis, Inflammatory bowel disease, Crohn disease, Colitis, ulcerative
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